Oncology - specialised tumor therapy

optimized treatment of peritonealcarcinoses
surgical oncology - regional chemotherapy

Pharmacokinetics

Intraperitoneal (IP) delivery of chemotherapy offers a potential therapeutic advantage over systemic chemotherapy by producing high regional concentrations of drug while simultaneously minimizing systemic toxicities. The selection of agents for perioperative intra-peritoneal chemotherapy is based on the drug's ability to produce a cytotoxic effect over a short time period and pharmacological data.

Mitomycin C, doxorubicin and cisplatin have a slow clearance from the peritoneal cavity. Pharmacokinetic studies of intraoperative intraperitoneal chemotherapy report an absorption of 75- 90% of the mitomycin C and cisplatin within the first hour.

Despite the greatly enhanced drug cytotoxicity because of high concentrations and heat synergy the technique is effective only in treating small volume peritoneal disease.

cytostatic drug molecular weight AUC Ratio
systemic vs. ip.
5-Fluorouracil 130 1 : 250
Irinotecan 677 1 : 18
Oxaliplatin 397 1 : 25
Cisplatin 300 1 : 20
Mitomycin 334 1 : 75
Doxorubicin 544 1 : 500
Mitoxantron 445 1 : 640
Paclitaxel 854 1 : 1000

Should you have any questions about the contents of this website or need more information as a patient, you may also get in contact with us. To correctly, gratuitous answer your queries all current documents, such as laboratory results, surgical reports and CT or MR images are required.
For submitting your request you can use the contact form

Herwart Müller, M.D.

Head of the Department of General Surgery in the Wertheim Hospital
E-Mail: Herwart.Mueller@swmbrk.de
Secretary: Anneliese Holzhäuser, Birgit Rauer
E-Mail: anneliese.holzhaeuser@swmbrk.de, birgit.rauer@swmbrk.de
Phone: +49 9342/303-5002
Fax:         +49 9342/303-5001
Reception: +49 9342/303-0
Rotkreuzklinik Wertheim gGmbH, Rotkreuzstr. 2
97877 Wertheim

Rotkreuzklinik Wertheim gGmbH

Abteilung für Allgemeinchirurgie
Rotkreuzstr. 2
97877 Wertheim / Bayern
Telefon:
+49 9342 / 303-5002