Oncology - specialised tumor therapy

optimized treatment of peritonealcarcinoses
surgical oncology - regional chemotherapy

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Peritonectomy and peritonealcarcinoses

Cytoreductive surgery means a complete removal of all visible tumors into the peritoneal cavity. It requires peritonectomy procedures eventually associated with multiple intestinal and/or organ resection.
The present knowledge of cell-kill kinetics with cytotoxic drugs indicates that, due to a larger proportion of cell growth fraction, micrometastases are more susceptible to chemotherapy than macroscopic ones, so that cancer cells free in the peritoneal cavity represent an ideal target of a locoregional treatment consisting in a high concentrated administration of cytotoxic drugs under hyperthermic conditions.

For the combination of hyperthermia and chemotherapy, spatial cooperation can explain the additive effects.

  • the efficacy of many drugs is potentiated by heat.
  • the addition of hyperthermia to chemotherapy can counteract drug resistance.
  • Increase in intracellular drug uptake
  • enhanced DNA damage
  • increase in intratumour drug concentrations, resulting from an increase in blood flow.

Indicationen for Cytoreductive surgery plus intraperitoneal chemotherapy

  • non invasive peritoneal carcinoses or sarcomatoses
  • peritoneal mesothelioma
  • limited peritonealcarcinose with invasive tumors
  • perforated primary gastrointestinal carcinoma
  • primary T4- gastrointestinal carcinome
  • primary gastrointestial Carcinome with positiv peritoneal cytology
  • Palliation von Patienten mit malignem Aszites

 

Should you have any questions about the contents of this website or need more information as a patient, you may also get in contact with us. To correctly, gratuitous answer your queries all current documents, such as laboratory results, surgical reports and CT or MR images are required.
For submitting your request you can use the contact form

Herwart Müller, M.D.

Head of the Department of General Surgery in the Wertheim Hospital
E-Mail: Herwart.Mueller@swmbrk.de
Secretary: Anneliese Holzhäuser, Birgit Rauer
E-Mail: anneliese.holzhaeuser@swmbrk.de, birgit.rauer@swmbrk.de
Phone: +49 9342/303-5002
Fax:         +49 9342/303-5001
Reception: +49 9342/303-0
Rotkreuzklinik Wertheim gGmbH, Rotkreuzstr. 2
97877 Wertheim

Rotkreuzklinik Wertheim gGmbH

Abteilung für Allgemeinchirurgie
Rotkreuzstr. 2
97877 Wertheim / Bayern
Telefon:
+49 9342 / 303-5002